## [Danny Lennon on the link between saturated fat and heart disease](https://twitter.com/NutritionDanny/status/1655918086107672578?s=20) Skeptics of the link between saturated fat and heart disease often cite a handful of studies finding a null results. In this twitter thread, Danny talks about one common issue in these studies: over adjustment. This occurs when studies looking for a link between saturated fat and heart disease control for blood lipids, but since blood lipids mediate this link, this biases the results toward a null result. > What happened in the Siri-Tarino MA [a study finding no link]? > > 42% of the weight of cardiovascular events in the paper was derived from studies which **controlled for blood lipids** 😐 Checkout the podcast episode: [#481: Why Saturated Fat Really Does Impact Heart Disease Risk | Sigma Nutrition](https://sigmanutrition.com/episode481/) GPT generated notes here: [[Sigma Nutrition - Why Saturated Fat Really Does Impact Heart Disease Risk]] ## [[The Hungry Brain]] I've started reading The Hungry Brain, a book on the neuroscience of weight gain. The notes for the introduction are up.